John R. Ipsaro


John is a well-rounded pharmaceutical litigator with a wealth of experience in virtually every aspect of drug litigation. For nearly 15 years, John has dedicated his practice to defending pharmaceutical companies in product liability and other mass tort claims. Recently recognized by The Best Lawyers in America© in the area of product liability, John has managed and handled virtually every aspect of tort litigation, from developing responsive pleading and removal strategies to final trial preparation and trial. He defends pharmaceutical companies in a variety of complex litigation matters across the country and has served as both lead and liaison counsel in significant multidistrict litigation proceedings involving hundreds of claimants. John’s ability and experience inform his pragmatic and client-driven approach to solving his clients’ problems.

Education & Admissions


  • State University of New York at Buffalo

    (B.S., Criminal Justice, magna cum laude, 1989)

  • University of Dayton School of Law

    (J.D., summa cum laude, 1993)
    Valedictorian; Law Review; Roger Turrell Memorial Scholarship Recipient


  • State of Ohio
  • Commonwealth of Kentucky
  • U.S. Court of Appeals, Sixth Circuit
  • U.S. Court of Appeals, Ninth Circuit
  • U.S. Court of Appeals, Eleventh Circuit
  • U.S. District Court, Southern District of Ohio
  • U.S. District Court, Northern District of Illinois



  • Acts as a key member of teams in multiple prominent mass torts and high-profile litigation, including as lead and liaison counsel in federal multidistrict and state mass tort proceedings, and actively manages all stages of pretrial proceedings.
  • Experience in complex cases involving a variety of classes of drugs, including antidepressants (selective serotonin reuptake inhibitors), aminosalicylates, fluoroquinolones, antiplatelets, testosterone replacement therapies, and bronchodilators.
  • Successfully defended various generic drug manufacturers in a range of cases alleging drug induced side effects, and has obtained dismissals on grounds ranging from judicial estoppel to preemption.
  • Skilled in many aspects of eDiscovery, including counseling clients on data preservation, initial assessments of data issues in new litigations, selection and retention of eDiscovery vendors, negotiations with opposing counsel regarding collection and production of electronically stored information, arguing in courts regarding discovery disputes, managing the collection, processing, review and production of materials responsive to discovery requests, and managing materials received in response to such requests.
  • Adept at identifying sources of valuable information from which to seek information from or about his adversaries, and putting that information to its best use in the litigation context.
  • Experience defending dozens of corporate fact and 30(b)(6) witness depositions from an array of disciplines typical to his pharmaceutical clients, including senior management, pharmacovigilance, regulatory affairs, medical affairs, professional affairs/medical information and communication, marketing, marketing research, sales, clinical/drug development, toxicology, pharmacology, informatics, and corporate compliance witnesses.
  • Experience taking depositions of fact-witness physician witnesses, including psychiatrists, internists, OB-GYNs, nephrologists, coroners, and multiple others.
  • Experience taking and defending expert witness depositions across a host of relevant disciplines, including drug-safety/pharmacovigilance, regulatory affairs, epidemiology, toxicology, pharmacology, and regulatory affairs.
  • Develops and implements strategies for his clients’ experts, and strategies to exclude (or limit) expert testimony of his adversaries through motion practice and evidentiary hearings pursuant to DaubertKemp, and similar expert admissibility standards.
  • Experience developing and preparing successful summary judgment and other dispositive motions resulting in dozens of dismissals over his career in state and federal trial and appellate courts throughout the country.
  • First-chair trial experience in multiple cases in which he was involved prior to joining the firm’s Product Liability Practice Group, and has handled complex settlement negotiations and issues in both one-off and mass tort settings.



  • Ohio State Bar Association
  • Cincinnati Bar Association
  • Kentucky Bar Association


  • Named to The Best Lawyers in America, Product Liability Litigation – Defendants; Commercial Litigation (2020-2024)